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. 2021 Nov;191(11):2009–2022. doi: 10.1016/j.ajpath.2021.07.006

Figure 2.

Figure 2

Morphologic and immunophenotypic dysplasia of miRZip-378a-3p (ZIP). A–C: Human CD34-positive hematopoietic stem cells (HSCs) were transfected with ZIP or scramble (SCR) vector and induced to mature by treatment with granulocyte colony-stimulating factor (G-CSF) for 9 days. Arrows indicate hypolobated neutrophils. A: untransduced human HSCs. B: HSCs transduced with SCR. C: HSCs transduced with ZIP. D–G: Myeloid markers of maturation on ZIP and SCR cell on days 0 (D0), Day 7 (D7) of all-trans retinoic acid treatment for HL60 cells and day 2 (D2) and day 9 (D9) of G-CSF treatment for HSCs. D and E: CD11b expression on HL60 cells (D) and HSCs (E). F and G: CD13 expression on HL60 cells (F) and HSCs (G). ∗P < 0.05. Original magnification, ×40 (Wright-Giemsa stain) (A–C).