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. 2021 Oct 22;18(16):3808–3820. doi: 10.7150/ijms.63401

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Generation of an osteochondral defect model in mice and study design. A full-thickness articular cartilage defect was generated in the central (weight-bearing) area of the medial femoral condyle in the mouse model (A). Models were treated by HA-g-CS implantation (B), moderate-intensity exercise and combination of the two treatments. Study design of the four groups was shown (C). BC: blank control group; HC: HA-g-CS implantation group; ME: moderate-intensity exercise group; HC+ME: HA-g-CS implantation plus moderate-intensity exercise group.