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. 2021 Nov 7;11(4):20458940211055996. doi: 10.1177/20458940211055996

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 1. — Berk-ss and Hbb^th/3+ mice develop pulmonary hypertension with remodeling: (a) Right ventricular systolic pressures. (b) Pulmonary vascular remodeling. (c) right ventricular weight. (d) Right ventricular to body weight ratio. (e) Left ventricle plus septum weight. (f) Fulton index (RV/LV+S). (g) Iron loaded cells accumulate in the lungs of Berk-ss and Hbb^th3/+ mice. *p < 0.01 vs. wild type; **p < 0.05 vs. wild type t-test; ***p = 0.013 vs. Hbb^th³^/+. L: vessel lumen; black arrows showing iron-loaded cells. (h) Mild RV interstitial fibrosis following Masson’s trichrome staining.