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Artesunate downregulated pro-inflammatory cytokines in the ischemic brain. The expression of interleukin (IL)-1β (a) and tumor necrosis factor (TNF)-α (b) in the cerebral cortex in different groups at 72 hours after distal middle cerebral artery occlusion (dMCAO) was detected by enzyme-linked immunosorbent assays (*P<0.05 vs the dMCAO group).
