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. 2021 Nov 8;30:09636897211052300. doi: 10.1177/09636897211052300

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — 6-OHDA lesioning significantly attenuated Meth –induced hyperactivity and stereotype behaviors in Meth -sensitized mice. (A) Timeline of experiment. Mice received a daily dose of Meth (2.5 mg/kg) or saline from day 0 to 6, and bilateral NAc lesioning by 6-OHDA on day 28. Meth (1 mg/kg)-induced locomotor activity was recorded on day 21 and 43. Meth–induced hyperactivity (B–D) and stereotype behavior (E) were significantly attenuated by 6-OHDA. Lesioning of NAc did not reduce locomotor activity in the non-sensitized (noS) mice. Sensitized mice (S) received repeated Meth injections. Non-sensitized mice (noS) received a repeated saline injection. *P < 0.05, 2-way ANOVA + NK test.