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. 2021 Feb 4;29(4):229–240. doi: 10.1177/1742271X20987584

Figure 6.

Figure 6.

Sal-B and Carvedilol therapeutic pathway. Pressure overload activates the beta-adrenergic receptors and ERK, promotes the expression of Gata4 and results in hypertrophy. Sal B could inhibit the ERK and beta-adrenergic receptors at the same time while Carvedilol only works as a beta-blocker.