Table 1:
Socio-demographic, cognitive, and clinical characteristics of the subjects
| AD+ AUD+ (N=52) | AD+ AUD− (N=701) | AD− AUD+ (N=67) | AD− AUD− (N=1283) | ANCOVA |
|||
|---|---|---|---|---|---|---|---|
| AD group main effect | AUD group main effect | AD × AUD interaction | |||||
|
| |||||||
| Age (yr) | 74.7 (9.6) | 77.0 (8.6) | 68.5 (10.0) | 71.2 (10.5) | F=40.7; p<0.0001 | F=7.0; p=0.008 | F=0.0; p=0.8 |
| Male % | 75% | 48% | 54% | 35% | χ2=47.8; p<0.0001 | χ2=27.8; p<0.0001 | --- |
| Education (yr) | 13.4 (4.2) | 15.0 (3.5) | 14.4 (4.3) | 15.7 (3.2) | F=6.9; p=0.009 | F=20.7; p<0.0001 | F=0.4; p=0.5 |
| CDR-SB | 6.1 (4.8) | 4.6 (3.8) | 0.4 (0.7) | 0.2 (0.5) | F=473.4; p<0.0001 | F=10.2; p=0.001 | F=7.6; p=0.006 |
| Semantic fluency | 18.4 (9.0) | 19.8 (8.6) | 33.9 (9.7) | 36.2 (9.0) | F=295.6; p<0.0001 | F=1.0; p=0.3 | F=0.9; p=0.3 |
| Trails A (s) | 62.5 (33.2) | 60.5 (36.3) | 36.8 (23.7) | 31.6 (14.9) | F=100.4; p<0.0001 | F=0.6; p=0.4 | F=0.9; p=0.4 |
| Trails B (s) | 193.7 (79.2) | 183.8 (79.8) | 104.7 (77.9) | 84.7 (48.3) | F=212.7; p<0.0001 | F=3.7; p=0.06 | F=1.4; p=0.2 |
| Cognitive PC1 | 1.2 (0.9) | 1.0 (0.9) | −0.3 (0.7) | −0.6 (0.5) | F=490.4; p<0.0001 | F=5.7; p=0.02 | F=0.0 p=0.9 |
Data presented as mean +/− SD. Age, sex, and education were used as covariates in the ANCOVA for CDR-SB, semantic fluency, and TMT A and B. R = right; L= left; AD+AUD+ = AD with history of alcohol use disorder; AD+AUD− = AD without a history of alcohol use disorder; AD−AUD+ = history of alcohol use disorder without AD; AD−AUD− = no history of AD or AUD. PC1: first principal component of the PCA of CDR-SB, semantic fluency, and TMTs. P values that met p<0.05, FDR-corrected are highlighted in bold.