Table 2:
Total gray matter, white matter, and ventricular volume
| AD+ AUD+ (N=52) | AD+ AUD− (N=701) | AD− AUD+ (N=67) | AD− AUD− (N=1283) | ANCOVA |
|||
|---|---|---|---|---|---|---|---|
| AD group main effect | AUD group main effect | AD × AUD interaction | |||||
|
| |||||||
| Total GMV | 567.6 (61.9) | 564.1 (61.8) | 597.8 (63.6) | 595.9 (62.6) | F=70.5; p<0.0001 | F=2.7; p=0.1 | F=0.0; p=0.9 |
| Total WMV | 441.6 (61.0) | 426.1 (56.0) | 460.3 (65.3) | 445.1 (64.4) | F=5.2; p=0.02 | F=0.1; p=0.8 | F=0.0; p=0.9 |
| Total LVV | 52.0 (29.7) | 49.3 (24.8) | 29.2 (15.4) | 29.8 (17.7) | F=83.2; p<0.0001 | F=0.7; p=0.4 | F=0.5; p=0.5 |
| Total TVV | 1.7 (0.6) | 1.7 (0.6) | 1.3 (0.6) | 1.2 (0.5) | F=25.9; p<0.0001 | F=0.1; p=0.7 | F=1.1; p=0.3 |
Data presented as mean +/− SD. Age, sex, education, and total intracranial volume were used as covariates in the ANCOVA. AD+AUD+ = AD with history of alcohol use disorder; AD+AUD− = AD without a history of alcohol use disorder; AD−AUD+ = history of alcohol use disorder without AD; AD−AUD− = no history of AD or AUD. GMV = gray matter volume; WMV = white matter volume; LVV = lateral ventricle volume; TVV = third ventricle volume. P values that met p<0.05, FDR-corrected are highlighted in bold.