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. 2021 Oct 11;17(15):4176–4191. doi: 10.7150/ijbs.67379

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Cul3 deficiency promotes Areg secrection to shape TME. (A) Comparison of cytokines released by CC cells isolated from SPC mice. (B) Heat-map shows comparison of cytokine levels. (C) qRT-PCR shows mRNA levels of Areg. (D) Western blot shows the activated Egfr signalling and increased Nrf2 level. (E) qPCR shows increased Areg transcription by Nrf2 overexpression. (F) Cul3 deficiency induced Areg expression is blocked by knocking out Nfe2l2. Dox is the abbreviation of doxycycline, and all the Cul3-deficient cells are doxycyclin-inducible cell line.^*P<.05, ^**P<.01, ^***P<.001, ^****P<.0001.