TABLE 5.
Fracture Risk in Individuals With Delayed Puberty
| Study (Reference) | Year | Name | N | Age at Evaluation, Years ± SD | Outcome Variable | Conclusion |
|---|---|---|---|---|---|---|
| Johnell et al64 | 1995 | MEDOS | 2086 women | 78.1 ± 9.4 | Hip fracture | RR: 1.45, 95% CI: 1.12 to 1.87 for age at menarche ≥15 y vs ≤11 y |
| Roy et al65 | 2003 | EPOS | 3173 men, 3402 women | 63.1 ± 7.8 (men), 62.2 ± 7.6 (women) | Vertebral fracture | RR: 1.8, 95% CI: 1.24 to 2.63 for age at menarche ≥16 y vs <16 y |
| Silman et al66 | 2003 | EPOS | 3173 men, 3402 women | 63.1 ± 7.8 (men), 62.2 ± 7.6 (women) | Colles’ fracture | RR: 1.5, 95% CI: 1.1 to 2.0 for age at menarche >15 y vs ≤15 y |
| Kindblom et al46 | 2006 | GOOD | 642 men | 18.9 ± 0.6 | Upper extremity fracture | OR: 1.39, 95% CI: 1.08 to 1.79, P = .01 for each 1-y increment to PHV |
| Chevalley et al63 | 2012 | 42 women | 20.4 ± 0.6 | Fracture | OR: 2.09, 95% CI: ∼1.3 to 3.3, P = .002 for each 1.2-y delay in menarche; mean age at menarche greater for fracture group vs no fracture group (13.45 vs 12.78, P = .003) |
CI, confidence interval; EPOS, European Prospective Osteoporosis Study; GOOD, Gothenburg Osteoporosis and Obesity Determinants; MEDOS, Mediterranean Osteoporosis Study; OR, odds ratio; RR, relative risk; PHV, peak height velocity.