Figure 2.
Oxygen sensing and cellular response (reproduced from Smith and Shumacker[15]). CaM, calmodulin; CRAC, calcium release-activated Ca2; DAG, diacylglycerol; IP3, inositol 1,4,5-trisphosphate; KV channels, voltage gated-potassium channel; MLC, myosin light chain; MLCK, myosin light chain kinase (MLCK); PIP2, phosphatidylinositol bisphosphate; PLC, phospholipase; ROCC, receptor-operated Ca2+ channels; ROS, reactive oxygen species; RyR, ryanodine receptors; SR, sarcoplasmic reticulum; VDCC, voltage-dependent Ca2+ channels