Table 2.
Associations of collagen fiber characteristics with the diagnoses of the regions of interest (ROIs) on diagnostic H&E-stained biopsies among women undergoing diagnostic breast biopsy
| Benign ROI vs. normal ROI (ref) | Cancer ROI vs. benign ROI (ref) | Cancer ROI vs. normal ROI (ref) | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Average length (μm) | 0.67 (0.51, 0.88) | 4.18 × 10–3 | 0.78 (0.56, 1.10) | 0.153 | 0.43 (0.25, 0.73) | 1.85 × 10–3 |
| Median straightness | 0.62 (0.46, 0.83) | 1.66 × 10–3 | 0.83 (0.60, 1.16) | 0.275 | 0.59 (0.39, 0.90) | 0.015 |
| Average width (μm) | 0.83 (0.65, 1.07) | 0.151 | 0.56 (0.36, 0.88) | 0.012 | 0.48 (0.31, 0.75) | 1.45 × 10–3 |
| Median alignment (in 44.91 μm × 44.91 μm) | 0.9 (0.68, 1.20) | 0.484 | 2.13 (1.28, 3.54) | 3.50 × 10–3 | 1.88 (1.07, 3.29) | 0.028 |
| Density (number of fibers/100 μm2) | 0.52 (0.38, 0.72) | 8.53 × 10–5 | 0.54 (0.34, 0.84) | 6.90 × 10–3 | 0.20 (0.06, 0.65) | 7.58 × 10–3 |
| Median orientation (°) | 0.79 (0.48, 1.3) | 0.353 | 0.94 (0.6, 1.47) | 0.782 | 1.17 (0.68, 2.03) | 0.569 |
Bold indicate statistically signficant associations
Based on generalized estimating equation (GEE) models with independent correlation structure. Outcomes of the models were the diagnosis of the ROI. Collagen fiber characteristics were the independent variables of the models. Models also included the case–control status of the woman. OR is per 1-standard deviation of the fiber characteristic
Ref: reference category. OR: Odds ratio