Table 2.
Cox regression analysis for predictors of 90-day mortality in 290 patients with HBV-ACLF in the derivation cohort
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | OR (95% CI) | P | |
| Parameter (model 1) | ||||||
| Age (years) | 1.030 | 1.016–1.045 | < 0.001 | |||
| Ascites (Y:N) | 3.882 | 2.380–6.330 | < 0.001 | |||
| HE (Y:N) | 9.931 | 6.445–15.302 | < 0.001 | 5.129 | 3.209–8.199 | < 0.001 |
| WBC (109 /L) | 1.150 | 1.114–1.187 | < 0.001 | |||
| NLR | 1.107 | 1.087–1.129 | < 0.001 | 1.067 | 1.038–1.096 | < 0.001 |
| Platelets (109 /L) | 0.996 | 0.992–0.999 | 0.025 | |||
| INR | 1.925 | 1.728–2.145 | < 0.001 | 1.487 | 1.310–1.687 | < 0.001 |
| TB (mg/dL) | 1.050 | 1.034–1.067 | < 0.001 | |||
| Albumin (g/L) | 0.970 | 0.935–1.005 | 0.096 | |||
| Creatinine (mg/dL) | 1.642 | 1.405–1.919 | < 0.001 | 1.269 | 1.043–1.545 | 0.017 |
| Sodium (mmol/L) | 0.911 | 0.884–0.939 | 0.001 | |||
| Lactate (mmol/L) | 1.282 | 1.214–1.354 | < 0.001 | 1.192 | 1.107–1.283 | < 0.001 |
| Parameter (model 2) | ||||||
| NLR grade | 4.725 | 3.364–6.636 | < 0.001 | 3.506 | 2.481–4.955 | < 0.001 |
| INR grade | 3.763 | 2.854–4.963 | < 0.001 | 2.400 | 1.803–3.193 | < 0.001 |
| TB grade | 1.745 | 1.393–2.185 | < 0.001 | |||
| Creatinine grade | 2.166 | 1.547–3.032 | < 0.001 | 1.727 | 1.278–2.335 | < 0.001 |
| Lactate grade | 1.857 | 1.479–2.332 | < 0.001 | |||
| HE grade | 4.349 | 3.442–5.496 | < 0.001 | 2.366 | 1.793–3.121 | < 0.001 |
HE hepatic encephalopathy, WBC white blood cell count, NLR neutrophil/lymphocyte ratio, INR international normalized ratio, TB total bilirubin, ACLF acute-on-chronic liver failure, HBV-ACLF hepatitis b related ACLF, AARC Asian Pacific Society for the Study of the Liver ACLF research consortium
Model 1 was adjusted for common variables. Model 2 was adjusted for three risk grades of NLR and five AARC-ACLF-related variables (include INR, TB, creatinine, lactate, and HE). Three risk grades of INR (< 1.8, 1.8–2.5, and > 2.5), TB (< 15 mg/dL, 15–25 mg/dL, and > 25 mg/dL), creatinine (< 0.7 mg/dL, 0.7–1.5 mg/dL, and > 1.5 mg/dL), lactate (< 1.5 mmol/L, 1.5–2.5 mmol/L, and > 2.5 mmol/L), and HE (< 3.10, 3.10–4.78, and > 4.78) were divided per the AARC ACLF scoring system. The corresponding three grades of NLR (< 3.10, 3.10–4.78, and > 4.78) was divided per the upper limit of normal and the optimal cut-off value evaluated in the sensitivity analyses in this cohort