Table 1.
Baseline characteristics according to tertiles of hs-CRP
| Tertiles of hs-CRP N = 1679 |
Tertile 1 n = 558 |
Tertile 2 n = 561 |
Tertile 3 n = 560 |
p-value |
|---|---|---|---|---|
| Range hs-CRP, mg/l | 0.13–1.35 | 1.35–3.22 | 3.22–9.97 | |
| Men, n (%)** | 434 (78) | 400 (71) | 361 (65) | < 0.05 |
| Age (years)* | 61 (10) | 61 (10) | 60 (10) | 0.11 |
| Hypertension* | 360 (65) | 401 (71) | 397 (71) | 0.07 |
| Smoking current, n (%)** | 80 (14) | 129 (23) | 188 (34) | < 0.05 |
| Pack-years*** | 9 IQR(0–26) | 13 IQR(0–31) | 16 IQR(2–33) | < 0.05 |
| Current alcohol use, n (%)** | 324 (58) | 258 (46) | 213 (38) | < 0.05 |
| Duration of diabetes (years)*** | 4 IQR(1–10) | 4 IQR(1–10) | 4 IQR(0–9) | 0.20 |
| BMI (kg/m2)* | 28 (4) | 29 (5) | 30 (5) | 0.19 |
| Systolic blood pressure, mmHg* | 144 (21) | 146 (22) | 146 (20) | 0.33 |
| Diastolic blood pressure, mmHg* | 83 (12) | 83 (12) | 83 (11) | 0.86 |
| Laboratory measurements | ||||
| Glucose, mmol/l* | 8.4 (2.6) | 8.6 (2.9) | 8.9 (3.1) | < 0.05 |
| HbA1c, %* | 6.8 (1.1) | 7.1 (1.3) | 7.2 (1.3) | < 0.05 |
| eGFR, ml/min/1.73 m2* | 80.3 (19.8) | 79.5 (23.0) | 77.5 (21.6) | 0.06 |
| Micro-albuminuria, n (%)** | 103 (20) | 128 (24) | 118 (23) | 0.31 |
| Total Cholesterol, mmol/l* | 4.5 (1.2) | 4.9 (1.4) | 5.0 (1.4) | < 0.05 |
| LDL-c, mmol/l* | 2.5 (1.0) | 2.8 (1.1) | 2.9 (1.1) | < 0.05 |
| HDL-c, mmol/l* | 1.2 (0.4) | 1.1 (0.3) | 1.1 (0.3) | < 0.05 |
| non-HDL-c, mmol/l* | 3.3 (1.2) | 3.4 (1.4) | 3.9 (1.4) | < 0.05 |
| Triglycerides, mmol/l*** | 1.5 IQR(1.0–2.2) | 1.7 IQR(1.2–2.5) | 1.8 IQR(1.3–2.7) | < 0.05 |
| Type of vascular disease | ||||
| Coronary artery disease, n (%)** | 270 (48) | 269 (48) | 226 (40) | < 0.05 |
| Cerebrovascular disease, n (%)** | 101 (18) | 97 (17) | 125 (22) | < 0.05 |
| Peripheral artery disease, n (%)** | 60 (11) | 74 (13) | 89 (16) | < 0.05 |
| Abdominal Aortic Aneurysm, n (%)** | 21 (4) | 27 (5) | 29 (5) | 0.32 |
BMI body mass index, eGFR estimated Glomerular Filtration Rate by the CKD-EPI equation, HDL-c high-density lipoprotein cholesterol, LDL-c low-density lipoprotein cholesterol
*Continuous variables are depicted as mean (SD), **count variables as n (%) and ***not normally distributed variables as median IQR