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. 2021 Nov 10;22:547. doi: 10.1186/s12859-021-04417-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Visualization of the ratios between multiple possible occurrences of EFVs found in a general polyhedron P (5) and the set of unique EFVs found in the cone shapes (FC (9), PC (7)) of EColiCore2 [29] with different reaction bounds applied (Table 2). The x-axis shows the ratio between the number of EFVs found in the cone shapes and the number of EFVs found in the polyhedron. The y-axis shows the factor between the run times of a flux cone FC and a general polyhedron P, respectively a polyhedral cone PC. The results of P and PC are arranged on the y-axis according to their factor. Along the dashed vertical line at (1, 0) the results from the polyhedral cone PC (blue) are located on the x-axis and according to their uniqueness accounted for as 1. The results from P (red) are arranged along the x-axis according to their multiples in comparison to the results of the cones. Each scenario was given a specific symbol as shown in the boxed legend