Table 3.
Summary of COVID-19 Vaccine Effectiveness in Fully Vaccinated Patients With Cancer
| Summary of COVID-19 Vaccine Effectiveness in Fully Vaccinated Patients With Cancer | |||||||
|---|---|---|---|---|---|---|---|
| Study | Country/Countries | Cancer Types | # of Patients or Control | Vaccine | # of Patients or Control | % Seroconversion | Median Titer Level (AU/mL or U/mL) |
| Gounant et al.61 | France | Thoracic | 269 | Mostly BNT162b2 | 269 | 94 | 4725 |
| Control | 13 | BNT162b2 | 13 | — | 10,594 | ||
| Goshen-Lago et al.49 | Israel | Various | 218 | BNT162b2 | 218 | 86 | — |
| Lung cancer | 43 | BNT162b2 | 43 | 86 | — | ||
| Massarweh et al.50 | Israel | Solid cancers | 102 | BNT162b2 | 102 | 90 | 1931 |
| Lung cancer | 26 | BNT162b2 | 26 | 92 | 1334 | ||
| Control | 78 | BNT162b2 | 78 | 100 | 7160 | ||
| Thakkar et al.51 | U.S. | Various | 200 | BNT162b2 | 115 | 95 | 5173 |
| Thoracic/head and neck | 25 | mRNA-1273 | 62 | 94 | 11,963 | ||
| Ad26.COV2.S | 20 | 85 | 1121 | ||||
| Control | 26 | — | — | — | >15,000 | ||
| Addeo et al.52 | Switzerland, U.S. | Various | 131 | BNT162b2 | 30 | 93 | 1232 |
| Thoracic malignancy | 18 | mRNA-1273 | 93 | 95 | 2500 | ||
| Barriere et al.5 | France | Solid cancers | 42 | BNT162b2 | 42 | 95 | 245 |
| Control | — | BNT162b2 | — | 100 | 2517 | ||
| Monin et al.53 | United Kingdom | Various | 24 | BNT162b2 | 24 | 79 | — |
| Control | 12 | BNT162b2 | 12 | 100 | — | ||
Note: Two-dose mRNA vaccines are highly effective (∼90%) in patients with cancer, though patients with cancer have lower titers than health controls.
#, number; AU, arbitrary unit; COVID-19, coronavirus disease 2019; U.S., United States.