TABLE 1.
Compensatory mutations, susceptibility, and major lineage of strains with rpoB resistance mutationse
| Mutation | Description | No. resistant | No. sensitive | MIC | Resistance type | No. in major lineage: |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||||||||
| rpoB RRDR nonresistance SNPs | rpoB compensatory | rpoA | rpoC | ||||||||
| Thr427Thra | 0 | 1 | NA | Pan-susceptible | 1 | ||||||
| Thr427Ala | 0 | 1 | ≤0.12 | Pan-susceptible | 1 | ||||||
| Arg447Arga | 0 | 2 | NA | Pan-susceptible | 2 | ||||||
| rpoB low-level resistance mutations | rpoB compensatory | rpoA | rpoC | ||||||||
| Ile59Thrd | 0 | 1 | 0.5 | Mono | 1 | ||||||
| Leu430Pro | 0 | 3 | 0.5–1 | 1 MDR, 2 mono | 1 | 1 | 1 | ||||
| Asp435Tyr | 0 | 1 | 0.5 | MDR | 1 | ||||||
| Ser441Gln | 0 | 1 | NA | MDR | 1 | ||||||
| His445Gln | 0 | 1 | 0.25 | Mono | 1 | ||||||
| Leu452Pro | 0 | 1 | 1–2 | Mono | 1 | ||||||
| Ile491Phed | Thr845Pro | 0 | 2 | 1–2 | Mono | 2 | |||||
| rpoB high-level resistance mutations | rpoB compensatory | rpoA | rpoC | ||||||||
| Val170Phed | Val183Gly | 1 | 0 | N/Ab | MDR | 1 | |||||
| Gln432Pro | Gly31Ser | 1 | 0 | >16 | MDR | 1 | |||||
| Asp435Val | 1 | 0 | NAb | MDR | 1 | ||||||
| His445Cys | 1 | 0 | >16 | MDR | 1 | ||||||
| His445Gly | His674Arg | 1 | 0 | >16 | MDR | 1 | |||||
| His445Tyr | Val731Metc | 1 | 0 | >16 | MDR | 1 | |||||
| His445Tyr | Glu513Gln | 1 | 0 | MDR | 1 | ||||||
| His445Tyr | Glu563Ala | 2 | 0 | MDR | 2 | ||||||
| Ser450Trp | 1 | 0 | >16 | MDR | 1 | ||||||
| Ser450Leu | Gly332Ser | 1 | 0 | >16 | MDR | 1 | |||||
| Ser450Leu | Gly433Ser | 2 | 0 | MDR | 2 | ||||||
| Ser450Leu | Phe452Ser | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Val483Ala | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Val483Gly | 3 | 0 | MDR | 1 | 2 | |||||
| Ser450Leu | Asp485Tyr | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Ile491Ser | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Asn698Lys | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Asn698Ser | 2 | 0 | MDR | 1 | 1 | |||||
| Ser450Leu | Asp735Asn | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Gly945Val | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Gly986Cys | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Pro1040Ser | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Pro1040Arg | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | 9 | 0 | 7 MDR, 2 Mono | 6 | 1 | 2 | |||||
| Ser450Leu | Arg552His | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Asp574Glu | 1 | 0 | MDR | 1 | ||||||
| Ser450Leu | Val534Ala | 1 | 0 | XDR | 1 | ||||||
| Ser450Leu | Lys258Thr, Ser1039Ala |
1 | 0 | MDR | 1 | ||||||
| Double rpoB mutations | rpoB compensatory | rpoA | rpoC | ||||||||
| Arg167Cys, Asp435Tyr |
1 | 0 | >16 | XDR | 1 | ||||||
| Asp435Ala, Leu452Pro |
Asp265Gly | 1 | 0 | >16 | MDR | 1 | |||||
a
Silent mutation.
b
Sample exhausted; no MIC result.
c
Heterozygous mutation.
d
Mutation located outside RRDR.
e
TB numbering system used for rpoB gene. NA, not applicable.