FIG 10.

Binding prediction of highly networked T-cell epitope derived peptides to additional HLA class II alleles and global population coverage. (a and c) The binding prediction of highly networked T-cell epitope derived peptides identified from the SARS-CoV-2 NC (a) and S protein (c). The binding prediction of 12-mer T-cell epitope derived peptides to HLA class II alleles are classified into four loci. The peptides with the top 5% bind levels to each of these additional HLA class II alleles are indicated as squares. The loci are indicated by different colors, as shown in the figure. (b and d) Percent global population coverage of highly networked T-cell epitope derived peptides identified from the NC (b) and the S protein (d). The most promising T-cell epitope derived peptides for HLA class II-mediated immune recognition are highlighted in red.