FIG 11.

Sequence comparison between highly networked T-cell epitope derived peptides identified by immunoinformatics analysis pipeline and other studies (12-mers). The highly networked T-cell epitope derived peptides (12-mers) were compared to the epitopes identified by Le Bert et al. (26) (gray), Grifoni et al. (43) (sky blue), Shomuradova et al. (44) (pink), Sekine et al. (16) (orange), and Peng et al. (29) (green). The highly networked T-cell epitopes which are most promising (i.e., those with network scores and percent bind level above the thresholds), unique, or both are indicated by blue rectangles in the figure. Also, the most promising peptides for an HLA class II-restricted immune response with <20% homology to four seasonal coronaviruses are indicated by blue rectangles.