FIG 4.

Binding prediction of highly networked T-cell epitope derived peptides to additional HLA class I alleles and global population coverage. (a and c) Binding predictions of highly networked T-cell epitope derived peptides identified from the SARS-CoV-2 NC (a) and S protein (c). The binding predictions for 9-mer T-cell epitope derived peptides to HLA-A and HLA-B alleles are classified into 10 supertypes (a and c). The peptides with top 5% bind levels to each of these additional HLA class I alleles are indicated as squares. The supertypes are indicated by different colors, as shown in the figure. (b and d) Percent global population coverage of highly networked T-cell epitope derived peptides identified from the NC (b) and S protein (d). The most promising T-cell epitope derived peptides for HLA class I-mediated immune recognition are highlighted in red.