TABLE 2.

Model parameter values and descriptions

Parameter	Value	Description	Reference(s)a
$k_e$	1.97	Antibiotic clearance (1/hour)	28
${\alpha }_S$	13.66	Growth rate of susceptible bacteria (1/hour)	28
${\alpha }_{\text{Rm}}$	1.9	Growth rate of bacteria resistant from mutation (1/hour)	28
${\alpha }_{\text{Rp}}$	2.1	Growth rate of bacteria resistant from plasmid (1/hour)	12, 19, 28
$N_{\text{max}}$	109	Carrying capacity (cells/milliliter)	30
$g_s,g_{\text{Rm}},g_{R1},g_{R2},g_{\text{Rp}}$	0	Bacterial influx rates (cells/hour)	NA
$k_T$	0	Bacterial efflux rate (1/hour)	NA
${\delta }_{\mathit{max},1} , {\delta }_{\mathit{max},2}$	27.14	Bacterial killing rate in response to antibiotic 1 and antibiotic 2 (1/hour)	28
$C_S^{50},C_{R,1}^{50}, C_{R,2}^{50}$	12.5, 100, 100	Antibiotic concn where the killing action is half its maximum value (microgram/milliliter)	Experimentally determined
$m_1\left(C_1\right)$	2.35 × 10−6 ($C_1)$	Mutation frequency under antibiotic 1 (1/hour)	8
$m_2\left(C_2\right)$	2.35 × 10−8 ($C_2$)	Mutation frequency under antibiotic 2 (1/hour)	8
β	0.001	Gene transfer rate (1/hour)	12

^aNA, not available.