TABLE 3.

Adjusted model parameter values and descriptions based on eVOLVER experimental conditions and results

Parameter	Value	Description
$k_e$	1.97	Antibiotic clearance (1/hour)
${\alpha }_S$	13.66	Growth rate of susceptible bacteria (1/hour)
${\alpha }_{R,1}$	4.99	Growth rate of bacteria resistant from mutation (1/hour)
${\alpha }_{S,1}$	8.3	Growth rate of bacteria semiresistant from mutation (1/hour)
$N_{\text{max}}$	3 × 108	Carrying capacity (cells/milliliter)
$g_s,g_{R,1},g_{S,1}$	0	Bacterial influx rates (cells/hour)
$k_T$	0.8	Bacterial efflux rate (1/hour)
${\delta }_{\mathit{max},1} , {\delta }_{\mathit{max},2}$	27.14	Bacterial killing rate in response to antibiotic 1 and antibiotic 2 (1/hour)
$C_S^{50},C_{S1}^{50}, C_{R,1}^{50}$	12.5, 100, 200	Antibiotic concn where the killing action is half its maximum value (microgram/milliliter)
$m_1\left(C_1\right)$	8.5 × 10−3 ($C_1$)	Mutation frequency of full resistance mutation (1/hour)
$m{s}_1\left(C_2\right)$	8.5 × 10−2 ($C_1$)	Mutation frequency of low resistance mutation (1/hour)