Skip to main content
. Author manuscript; available in PMC: 2022 Aug 20.
Published in final edited form as: Free Radic Biol Med. 2021 Jul 2;172:562–577. doi: 10.1016/j.freeradbiomed.2021.07.002

Fig. 3.

Fig. 3.

S-Nitrosylation of parkin and Uch-L1 impairs UPS activity. Aberrant S-nitrosylation of parkin disrupts its ubiquitin E3 ligase activity. S-Nitrosylated Uch-L1 manifests decreased deubiquitinase activity and increased transnitrosylation activity. Aberrant protein S-nitrosylation eventually impairs the function of the UPS, contributing to the accumulation of misfolded and aggregated proteins.