Table 3 –
Genetic etiology of arrhythmogenic cardiomyopathy
| Gene | Protein | Chr | Mode of inheritance | Pediatric frequency | OMIM | Reference |
|---|---|---|---|---|---|---|
| DES | Desmin | 2q35 | AD | ~3% | 125660 | 115 |
| DSC2 | Desmocollin 2 | 18q 12 | AD, AR | ~3% | 125645 | 74, 94, 106, 115 |
| DSG2 | Desmoglein 2 | 18q12-q12 | AD | ~10% | 125671 | 74, 94, 106, 115 |
| DSP | Desmoplakin | 6p24 | AD, AR | ~6–13% | 125647 | 74, 106, 115 |
| JUP | Plakoglobin | 17q21 | AD, AR | Rare | 173325 | 74, 94, 115 |
| LMNA | Lamin A/C | 1q22 | AD | ~10% | 150330 | 95, 107, 115 |
| PKP2 | Plakophilin 2 | 12p 11 | AD | 30–45% | 602861 | 94, 106, 113, 115 |
| PLN | Phospholamban | 6q22 | AD | Rare | 172405 | 115 |
| TMEM43 | Transmembrane protein 43 | 3p25 | AD | Rare | 612048 | 106, 115 |
AD, autosomal dominant; AR, autosomal recessive; XD, X-linked dominant; XL, X-linked; XR, X-linked recessive