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. 2021 Nov 10;9(3):e00965-21. doi: 10.1128/Spectrum.00965-21

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Copyright © 2021 Nitahara et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — Linear epitopes in the receptor binding domain (RBD) identified only in vaccine recipient sera. Angiotensin converting enzyme2 (ACE2) is shown in green. (a) The RBD is shown in tint blue. Linear epitope N334 to A348 (peptide no. 6), magenta. (b) SARS-CoV-2 spike trimer in one open, two closed (one RBD up, two RBD up) composition. Spike subunit 2 and N-terminal domain are in the same color, light blue, yellow, and tint blue. Up RBD is in dark blue. Down RBDs are in yellow. Linear epitope N334 to A348 has good accessibility in both the up and down composition of the RBD. (c) The RBD, green. Linear epitope S373 to L390 (peptide no. 19 and 20), orange.