Table 2.
Comparison of DENV infection characteristics in different animal models
| Characteristic | Animal model |
|---|---|
| Viral replication | |
| High viremia | AG129 mice; humanized mice; marmoset; bonnet macaque |
| Low viremia | Rhesus macaque; chimpanzee; C57BL/6; BALB/c mice; tree shrew |
| Clinical signs | |
| Dengue clinical manifestations | Humanized mice; AG129 mice (DENV serotype and mice-age dependent) |
| Fever | Marmoset; humanized mice, tree shrew |
| Thrombocytopenia | Humanized mice; AG129 mice; marmoset; tree shrew |
| Leukopenia | Marmoset |
| Skin rash | Swine |
| Liver involvement | AG129 mice; C57BL/6 mice |
| Kidney involvement | C57BL/6 mice; BALB/c mice |
| Vascular leak syndrome | AG129 mice (DENV-2 infection) |
| Neurological signs (not commonly seen in human dengue) | AG129 mice |
| Immune response | |
| Seroconversion | Marmoset; bonnet macaque; chimpanzee; mice; tree shrew; swine |
| Production of neutralizing antibodies | Chimpanzee; rhesus monkey; cynomolgus monkey; marmoset; mice models |
| T cell immunity | Marmoset |
| Antibody-dependent enhancement | Rhesus macaque; LysM Cre(+) Ifnar(flox/flox) mice; AG129 mice |