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Subcutaneous injection of IGF-2 or M6P enhances Y-maze behavioral flexibility in WT males but not females. Percent of correct alternations in a Y-maze spontaneous alternation test in WT and Ube3am−/p+ male mice (left panel) and female mice (right panel). All data are expressed as means ± s.e.m.; n = 3–9 per group. Two-way analysis of variance (ANOVA) followed by Tukey’s post-hoc tests. *P < 0.05, **P < 0.01, ***P < 0.001.
