Linker design. PDBbind set results (see Methods, Evaluation metrics for definitions of the metrics).

Metric	SyntaLinker	DeLinker	DeLinker-Counts	DEVELOP
Valid	65.4%	96.9%	90.2%	93.1%
Unique	9.0%	86.1%	77.8%	77.3%
Novel	9.9%	84.0%	87.6%	88.7%
Recovered	0.0%	1.9%	8.7%	22.4%
Pass 2D filters	95.1%	63.4%	59.5%	61.7%
SC RDKit generated
>0.6	13.4%	10.4%	19.8%	27.9%
>0.7	7.7%	4.2%	10.1%	14.8%
>0.8	4.8%	1.5%	4.4%	6.1%
>0.9	1.3%	0.4%	1.2%	1.5%