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. 2021 Oct 19;12(43):14606–14617. doi: 10.1039/d1sc04019g

Scheme 3. Synthesis of the EF-building block for F-variations. Conditions: a SOCl2, 95 °C, then amine 25a (80%) or 25b (79%), NEt3, THF, 0 °C → 25 °C; bi Zn, EtOH/AcOH (4 : 1), 0 °C → 25 °C, 25a (30%), 25b (96%), 26 (32%); bii Zn, CHCl3/AcOH (9 : 1), 0 °C → 25 °C, 25a (96%).

Scheme 3