Pharmacokinetic properties for 2 and 7 after i.v. administration of 50 mg kg−1 compared to the cystobactamid analogue CYS-22.32.
| PK parameter | 2 | 7 | CYS-22 |
|---|---|---|---|
| 50 mg kg−1 | 50 mg kg−1 | 5 mg kg−1 | |
| AUC [ng mL h−1] | 153 320.0 ± 47 239.0 | 224 852.0 ± 49 029.0 | 2087.0 ± 573.1 |
| T 1/2 [h] | 1.2 ± 0.6 | 1.373 ± 1.5 | 0.98 ± 0.1 |
| V Z [L kg−1] | 4.9 ± 5.2 | 2.7 ± 1.1 | 3.5 ± 1.2 |
| CL [mL h−1 kg−1] | 352.4 ± 128.6 | 229.2 ± 47.5 | 2490 ± 684 |