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. 2021 Oct 19;12(43):14606–14617. doi: 10.1039/d1sc04019g

Pharmacokinetic properties for 2 and 7 after i.v. administration of 50 mg kg−1 compared to the cystobactamid analogue CYS-22.32.

PK parameter 2 7 CYS-22
50 mg kg−1 50 mg kg−1 5 mg kg−1
AUC [ng mL h−1] 153 320.0 ± 47 239.0 224 852.0 ± 49 029.0 2087.0 ± 573.1
T 1/2 [h] 1.2 ± 0.6 1.373 ± 1.5 0.98 ± 0.1
V Z [L kg−1] 4.9 ± 5.2 2.7 ± 1.1 3.5 ± 1.2
CL [mL h−1 kg−1] 352.4 ± 128.6 229.2 ± 47.5 2490 ± 684