Table 3.

Brain regions that exhibited a reliable increase in variability on drug compared with placebo in older adults alone

Cluster number	MNI co-ordinates			Peak threshold (BSR)	Cluster size (in 2 mm voxels)	Cortical region label based on Harvard-Oxford cortical atlas
	X	Y	Z
1	−22	10	−26	6.94	7991	(L) Orbitofrontal cortex (includes parts of left temporal pole, superior temporal gyrus, planum temporalis)
2	34	−8	−30	6.54	8189	(R) Temporal fusiform cortex (includes parts of right superior temporal, parahippocampal, temporal pole, middle temporal gyrus)
3	36	−50	−20	6.49	7280	(R) Temporal fusiform cortex (includes parts of occipital fusiform cortex)
4	50	40	22	6.34	1465	(R) Frontal pole
5	4	−86	−38	6.03	323	Bilateral cerebellum Crus2 (AAL based)
6	−6	−34	58	5.98	7844	(L) Precentral gyrus (includes parts of bilateral precentral gyrus, supplementary motor area, superior frontal cortex, cingulum)
7	62	−2	36	5.89	1121	(R) Precentral Gyrus
8	14	−60	56	5.81	217	(R) Lateral occipital cortex (superior division; includes parts of superior parietal lobule and precuneus)
9	−26	−72	−10	5.79	906	(L) Occipital fusiform cortex
10	−26	46	42	5.34	587	(L) Frontal pole
11	−14	−102	6	5.31	169	(L) Occipital pole
12	24	4	−40	5.22	585	(R) Temporal pole
13	−44	32	40	4.94	231	(L) Middle frontal gyrus
14	−62	4	8	4.83	202	(L) Precentral gyrus
15	−50	−6	48	4.59	205	(L) Precentral gyrus
16	−16	62	−18	4.59	365	(L) Frontal pole
17	18	60	30	4.28	109	(R) Frontal pole
18	−44	−70	38	4.13	129	(L) Lateral occipital cortex (superior division)
19	−50	44	−8	3.88	128	(L) Frontal pole
20	−44	−68	−2	3.65	103	(L) Lateral occipital cortex (inferior division)

L = left hemisphere; R = right hemisphere.