Table 5.

Brain regions that exhibited a reliable association between cognitive processing score from the NIH toolbox and brain signal variability measure during placebo and drug condition as well as drug-related change in brain signal variability in older adults alone

Cluster number	MNI co-ordinates			Peak threshold (BSR)	Cluster size (in 2 mm voxels)	Cortical region label based on Harvard-Oxford cortical atlas
	X	Y	Z
1	18	−40	4	10.224636	621	(R) Cingulate gyrus (posterior division; includes parts of parahippocampal gyrus)
2	20	4	0	9.2745419	1370	(R) Pallidum
3	12	−46	62	8.2238169	4322	(R) Postcentral gyrus (includes parts of left postcentral gyrus, and bilateral precentral gyrus, precuneus, lateral occipital cortex)
4	−52	−28	28	7.7824106	2399	(L) Supramarginal gyrus (anterior division; includes parts of Heschl's gyrus, central opercular cortex)
5	30	−72	38	7.6328068	510	(R) Lateral occipital (superior division; includes parts of right superior parietal lobule)
6	44	−16	−4	7.184948	387	(R) Planum polare (includes parts of Heschl's gyrus, superior temporal gyrus)
7	40	32	18	7.0990481	252	(R) Middle Frontal Gyrus
8	2	20	38	6.6304259	260	Paracingulate gyrus (posterior division; includes parts of angular division of cingulate gyrus)
9	−58	10	−2	6.3138566	260	(L) Inferior temporal gyrus (pars opercularis)
10	32	28	36	6.1835728	400	(R) Middle frontal gyrus
11	−28	30	−6	6.1152315	259	(L) Frontal orbital cortex
12	−42	−60	4	5.9749165	164	(L) Lateral occipital cortex (inferior division)
13	−26	8	−42	5.5768657	161	(L) Temporal pole
14	−8	16	58	5.5280857	207	(L) Superior frontal gyrus
15	12	46	−20	5.4033055	1406	(R) Frontal pole
16	−36	−12	−24	5.3511524	234	(L) Parahippocampal gyrus (anterior division; includes parts of temporal fusiform cortex)
17	−36	8	14	5.3335013	467	(L) Central opercular cortex (includes parts of frontal operculum cortex)
18	26	6	−44	5.3303905	102	(R) Temporal pole
19	22	54	22	4.8249021	245	(R) Frontal pole

L = left hemisphere; R = right hemisphere.