Table 4.
Variations at Amino Acid Residues of Interest Among 1177 Complete-Length Neuraminidase (NA) Gene Sequences of Influenza A(H7N9) Viruses Available in the GISAID Database, 1 January 2013–25 July 2016
| NA Residue | Amino Acida | Amino Acid Change | Sequences With Amino Acid Change, No. | Accession Numbers (Passage History) | ||
|---|---|---|---|---|---|---|
| N2 | Avian N9 | 2013 N9 | ||||
| 119 | 120 | 115 | Eb | V | 5 | EPIISL 141162 A/Jiangsu/02/2013 (E1); |
| EPIISL 158942 A/Taiwan/01/2013 (E1/S2); | ||||||
| EPIISL 192328 A/Anhui/01881/2014 (E1); | ||||||
| EPIISL 192348 A/Zhejiang/16/2014 (E1); | ||||||
| EPIISL 192354 A/Guangdong-Guangzhou/XN14670/2014 (E1) | ||||||
| Y | 2 | EPIISL 206852 Am/chicken/Huai’an/007/2014 (NR); | ||||
| EPIISL 206854 A/chicken/Huai’an/053/2014 (NR) | ||||||
| 152 | 153 | 148 | R | K | 3 | EPIISL 141174 Am/Shanghai/9/2013 (E1); |
| EPIISL 175722 A/silkie_chicken/Dongguan/3990/2013 (E1); | ||||||
| EPIISL 192505 A/Zhejiang/9/2015 (E1) | ||||||
| T | 1 | EPIISL 206853 A/Huai’an/062/2014 (NR) | ||||
| 222 | 224 | 219 | I | K | 1 | EPIISL 158944 A/Taiwan/01/2013 (E1/S2/NA/I222K) |
| R | 1 | EPIISL 158943 A/Taiwan/01/2013 (E1/S2/NA/I222R) | ||||
| 292 | 294 | 289 | Rc | K | 13 | EPIISL 138737 A/Shanghai/1/2013 (E1); |
| EPIISL 141186 A/Jiangsu/07/2013 (E1); | ||||||
| EPIISL 141166 A/Shanghai/06-A/2013 (E1); | ||||||
| EPIISL 142187 A/Taiwan/S02076/2013 (NR); | ||||||
| EPIISL 155053 A/Taiwan/01/2013 (E1/S2/NA/R292K); | ||||||
| EPIISL 155654 Am/Shanghai/5190Tm/2013 (NR); | ||||||
| EPIISL 166435 Am/Zhejiang/LS01/2014 (NR); | ||||||
| EPIISL 175835 A/Shenzhen/SP44/2014 (NR); | ||||||
| EPIISL 190691 A/Quzhou/1/2015 (NR); | ||||||
| EPIISL 192344 A/Zhejiang/22/2014 (E1); | ||||||
| EPIISL 192371 A/Guangdong-Guangzhou/XN00429/2014 (E1); | ||||||
| EPIISL 192377 A/Shandong/01/2014 (E1); | ||||||
| EPIISL 192440 A/Zhejiang/07803/2014 (E1) | ||||||
The variations at the following amino acid positions were analyzed: 119, 136, 152, 222, 247, 274, 276, 292, 294, and 371 (N2 numbering). 2013 N9-specific numbering accounts for the amino acid residue deletion at positions 64–8.
Abbreviation: NR, not reported.
Residue in influenza A/Victoria/361/2001(H3N2), A/Anhui/1/2013(H7N9), and A/tern/Australia/G70C/1975(H11N9) viruses.
Three sequences have indeterminate (ie, “x”) nucleotide(s) within the triplet encoding amino acid residue 119.
Two sequences have indeterminate (ie, “x”) nucleotide(s) within the triplet encoding amino acid residue 292.