Table 9. Summary of Recipient Plasma Ig Isotype Concentrations Over Time.
| Track 2 | Track 3 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ig Isotype± | Day | Range | Median | IQR | Mean | SD | % Elevated* | Ig Isotype± | Day | Range | Median | IQR | Mean | SD | % Elevated* | P Value^ |
| IgM | Pre-Inf | 29.46–1526.64 | 500.87 | 405.72 | 635.81 | 355.04 | 4.3 | IgM | Pre-Inf | 191.47–1810.14 | 545.92 | 504.78 | 651.91 | 464.52 | 8.3 | 0.460 |
| 3 | 96.45–1377.92 | 614.29 | 387.09 | 607.07 | 328.10 | 0.0 | 3 | 349.14–2085.05 | 552.00 | 368.72 | 691.10 | 488.77 | 8.3 | 0.300 | ||
| 10 | 63.78–2043.42 | 868.66 | 565.72 | 921.22 | 497.52 | 13.6 | 10 | 179.98–2821.53 | 464.56 | 312.31 | 711.68 | 767.45 | 10.0 | 0.220 | ||
| IgG1 | Pre-Inf | 467.84–3394.79 | 1508.58 | 1145.05 | 1686.83 | 763.37 | 0.0 | IgG1 | Pre-Inf | 598.72–5565.71 | 1574.16 | 1065.04 | 1958.64 | 1405.92 | 8.3 | 0.270 |
| 3 | 633.39–4377.47 | 2538.12 | 1137.61 | 2467.19 | 892.29 | 0.0 | 3 | 1215.2–5223.11 | 2320.29 | 1176.69 | 2692.29 | 1212.88 | 0.0 | 0.290 | ||
| 10 | 471.80–6585.11 | 3930.08 | 1608.61 | 3805.31 | 1515.92 | 22.7 | 10 | 1572.9–8232.79 | 2293.49 | 1498.74 | 3130.42 | 1963.08 | 10.0 | 0.180 | ||
| IgG2 | Pre-Inf | 557.28–7485.44 | 1592.47 | 1011.59 | 1836.37 | 1387.54 | 4.3 | IgG2 | Pre-Inf | <41.15–3593.54 | 1682.12 | 768.71 | 1783.23 | 802.90 | 16.7 | 0.440 |
| 3 | 245.53–2398.19 | 1113.82 | 636.61 | 1151.99 | 505.30 | 0.0 | 3 | 100.52–3137.44 | 1171.52 | 676.67 | 1193.21 | 800.61 | 8.3 | 0.440 | ||
| 10 | 134.93–4841.17 | 1787.83 | 1014.11 | 1798.30 | 1126.12 | 13.6 | 10 | 252.67–3685.76 | 1338.09 | 1366.52 | 1519.90 | 1100.62 | 20.0 | 0.260 | ||
| IgG3 | Pre-Inf | 6.53–2221.34 | 299.54 | 290.13 | 500.98 | 589.09 | 13.0 | IgG3 | Pre-Inf | 14.99–2119.72 | 280.21 | 259.16 | 396.59 | 563.87 | 8.3 | 0.310 |
| 3 | 28.51–2952.21 | 530.21 | 533.48 | 656.51 | 716.05 | 13.0 | 3 | 64.43–2204.29 | 425.58 | 479.70 | 539.44 | 582.10 | 8.3 | 0.300 | ||
| 10 | 14.40–4081.00 | 811.41 | 2042.62 | 1409.24 | 1232.84 | 45.5 | 10 | 76.30–3378.10 | 387.27 | 524.82 | 705.34 | 998.16 | 20.0 | 0.051 | ||
| IgG4 | Pre-Inf | 1.28–5284.39 | 300.04 | 598.12 | 1098.00 | 1771.44 | 26.1 | IgG4 | Pre-Inf | 0.51–1164.21 | 160.33 | 372.93 | 325.26 | 392.26 | 16.7 | 0.028 |
| 3 | 15.36–6012.85 | 162.98 | 532.31 | 963.40 | 1833.56 | 17.4 | 3 | 15.56–6955.33 | 224.07 | 1326.54 | 1457.64 | 2421.05 | 25.0 | 0.270 | ||
| 10 | 5.34–9193.77 | 233.81 | 3142.14 | 1883.73 | 2942.47 | 36.4 | 10 | 8.04–2810.92 | 177.82 | 606.66 | 657.25 | 969.69 | 30.0 | 0.045 | ||
| IgA | Pre-Inf | 55.41–1885.00 | 1102.55 | 843.81 | 976.95 | 485.37 | 4.3 | IgA | Pre-Inf | 36.17–3076.73 | 825.90 | 1251.37 | 1193.87 | 910.19 | 25.0 | 0.230 |
| 3 | 127.47–1933.61 | 911.67 | 454.89 | 947.59 | 419.35 | 4.3 | 3 | 156.41–2479.88 | 1153.34 | 798.39 | 1177.55 | 676.74 | 16.7 | 0.150 | ||
| 10 | 85.53–3362.65 | 1279.64 | 670.32 | 1328.39 | 735.01 | 13.6 | 10 | 568.51–2323.40 | 970.27 | 524.68 | 1163.83 | 612.29 | 10.0 | 0.260 | ||
±Unit is ug/ml
* The % of recipients with plasma values elevated above the normal control mean + 2xSD
^T-test was used to compare Means of Track 2 and Track 3; Statistically significant p values are highlighted in gray
SD, Standard Deviation of the Mean; IQR, Interquartile Range; Pre-Inf, Pre-Convalescent Plasma Infusion