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. 2021 Nov 10;7(46):eabi8178. doi: 10.1126/sciadv.abi8178

Fig. 8. Secondary validation of incipient AD proteomic signature.

Fig. 8.

(A and B) Results of validation analyses carried out with publicly available proteomic and transcriptomic datasets. Colored squares represent proteins/genes that were differentially abundant/expressed between AD and CN or 5xFAD versus WT mice. Gray squares indicate proteins/transcripts that were not quantified (N.Q.). White squares indicate proteins/transcripts that were not significantly (N.S.) differentially abundant/expressed between AD and CN or 5xFAD versus WT mice. Significance was defined as P < 0.05. scRNA, single-cell RNA; LC-MS/MS, liquid chromatography with tandem MS.