Table 1. Cohort demographics.
BLSA, Baltimore Longitudinal Study of Aging; YAPS, Young APOE Postmortem Study; ROS, Religious Orders Study; Disease duration, age death − age onset; MMSE, Mini Mental State Exam (last available before death); APOE ε4+, APOE e4 carrier; APOE ε4−, APOE e4 noncarrier. Note: The Wilcoxon rank sum (Mann-Whitney) test and χ2 test were used to test for differences in continuous and binary variables, respectively.
| BLSA | |||
| Total sample | AD | CN | |
| N = 52 | N = 31 | N = 21 | |
| Age at death, mean (SD) | 86.26 (10.50)* | 88.46 (8.30)* | 83.02 (12.63) |
| Age of onset, mean (SD) | – | 78.81 (9.92)* | |
| Disease duration, mean (SD) | – | 9.65 (4.47)* | |
| Sex, n (% female) | 22 (42.31)* | 15 (48.39)* | 7 (33.33) |
| Race, n (% white) | 49 (94.23) | 31 (100)† | 18 (85.71)† |
| APOE e4 carrier, n (%) | 14 (28.00) | 9 (31.03) | 5 (23.81) |
| MMSE, mean (SD) | 24.66 (5.59) | 21.60 (6.05)*† | 28.06 (1.98)† |
| CERAD, mean (SD) | 1.73 (1.34) | 2.77 (0.43)† | 0.19 (0.40)† |
| Braak, mean (SD) | 4.10 (1.67) | 5.13 (1.12)*† | 2.57 (1.08)† |
| PMI (hours), mean (SD) | 15.58 (10.01)* | 16.25 (11.73)* | 14.53 (6.63)* |
| ROS | |||
| Total sample | AD | CN | |
| N = 53 | N = 31 | N = 22 | |
| Age at death, mean (SD) | 90.58 (6.53)* | 92.81 (5.45)*† | 87.44 (6.75)† |
| Age of onset, mean (SD) | – | 89.14 (5.71)* | – |
| Disease duration, mean (SD) | – | 3.67 (2.94)* | – |
| Sex, n (% female) | 40 (75.47)* | 27 (87.10)*† | 13 (59.09)† |
| Race, n (% white) | 53 (100.00) | 31 (100.00) | 22 (100.00) |
| APOE e4 carrier, n (%) | 13 (25.49) | 9 (31.03) | 4 (18.18) |
| MMSE, mean (SD) | 19.95 (10.10) | 12.77 (8.43)*† | 28.50 (1.59)† |
| CERAD, mean (SD) | 1.64 (1.26) | 2.58 (0.50)† | 0.32 (0.65)† |
| Braak, mean (SD) | 3.89 (1.33) | 4.65 (0.66)*† | 2.82 (1.30)† |
| PMI (hours), mean (SD) | 9.05 (5.32)* | 8.67 (5.36)* | 9.59 (5.35)* |
| YAPS | |||
| Total sample | APOE ε4+ | APOE ε4− | |
| N = 35 | N = 18 | N = 17 | |
| Age at death, mean (SD) | 38.97 (5.95) | 39.06 (6.15) | 38.88 (5.93) |
| Sex, n (% female) | 13 (37.14) | 6 (33.33) | 7 (41.18) |
| Race, n (% white) | 25 (71.43) | 14 (77.78) | 11 (64.71) |
| PMI (hours), mean (SD) | 23.14 (11.42) | 24.39 (12.46) | 21.82 (10.42) |
*P < 0.05 comparing BLSA to ROS (e.g., AD in BLSA compared to AD in ROS).
†P < 0.05 comparing AD to CN.