Table 4.

Maximal toxicity per patient.

	Grade I-II	Grade III	Grade IV
Overall toxicities [n (%)]	21 (35)	30 (50)
Non hematologic toxicities [n (%)]	14 (23)	15 (25)
Cutaneous	12 (20)	7 (12)	0
Neuropathy	3 (5)	2 (3)	0
Electrolytes disorders	3 (5)	5 (8)	2 (3)
Infusion reaction	3(5)	1 (2)	0
Nausea	5 (8)	0	0
Diarrhea	4 (7)	1 (2)	0
Hematologic toxicities [n (%)]	17 (28)	21 (35)
Neutropenia	30 (50)	8 (13)	7 (12)
Anemia	26 (43)	7 (12)	0
Thrombopenia	7 (12)	1 (2)	0
Toxicity-related data [n (%)]
Blood transfusion	18 (30)
EPO (secondary prophylaxis)	9 (15)
G-CSF (primary prophylaxis)	4 (7)
G-CSF required (secondary prophylaxis)	30 (50)
Febrile neutropenia	6 (10)
Hospitalisation due to infection	16 (27)
Hospitalisation	26 (43)
Deaths in association with AEs	4 (6,6)