Table 1. Characteristics of studies in this meta-analysis.

Study	Year	Country	Tumor types	Sample size	Sample	Detection method	Cut off value	Follow-up (year)	Outcome measures	Extract method	NOS
Jia	2020	China	neuroblastoma	45	tissues	qRT-PCR	mean	5 years	OS	K-M Curve	8
Shen	2020	China	hepatocellular carcinoma	100	tissues	qRT-PCR	mean	5 years	PFS OS	K-M Curve	7
Zhang	2020	China	synchronous colorectal liver metastasis	96	serum	qRT-PCR	median	3 years	OS	Reported	8
Wu	2020	China	cervical cancer	51	tissues	qRT-PCR	median	5 years	OS	K-M Curve	7
Xia	2020	China	prostate cancer	127	tissues	qRT-PCR	mean	5 years	OS	Reported	8
Zhang	2020	China	gastric cancer	162	tissues	qRT-PCR	median	8 years	OS	Reported	9
Zeng	2019	China	cervical cancer	60	tissues	qRT-PCR	NA	5 years	OS	Reported	8
Yang	2019	China	hepatocellular carcinoma	80	tissues	qRT-PCR	median	5 years	OS	K-M Curve	8
Yao	2019	China	hepatic carcinoma	40	tissues	qRT-PCR	median	3 years	OS	K-M Curve	7
Cheng	2019	China	pancreatic cancer	40	tissues	qRT-PCR	NA	3.5 year	OS	K-M Curve	7
Wu	2019	China	hypopharyngeal cancer	73	tissues	qRT-PCR	median	5 years	OS	K-M Curve	8
Chi	2019	China	neuroblastoma	92	tissues	qRT-PCR	mean	5 years	OS	K-M Curve	8
Luo	2018	China	breast cancer	72	tissues	qRT-PCR	NA	6.5 years	OS	K-M Curve	7
Chen	2019	China	bladder cancer	92	tissues	qRT-PCR	NA	5 years	OS	K-M Curve	8
Deng	2018	China	osteosarcoma	30	tissues	qRT-PCR	median	5 years	OS	K-M Curve	7
Li	2018	China	colorectal cancer	53	tissues	qRT-PCR	NA	5 years	OS DFS	Reported/ K-M Curve	8
Qi	2018	China	prostate cancer	42	tissues	qRT-PCR	NA	5 years	OS	K-M Curve	7
Shan	2018	China	colorectal cancer	48	tissues	qRT-PCR	median	5.5 years	OS	K-M Curve	7