TABLE 4. Performance Metrics for Using Shannon and Sample Entropies to Detect Liver Fibrosis in Individuals With Moderate-to-Severe Hepatic Steatosis.

	F1		F2		F3		F4
Parameter	Shannon entropy	Sample entropy	Shannon entropy	Sample entropy	Shannon entropy	Sample entropy	Shannon entropy	Sample entropy
Cutoff value	3.86	1.94	3.78	1.88	3.77	1.88	3.79	1.87
Sensitivity, %	93.10	94.83	52.38	75.00	40.00	77.14	57.89	84.21
Specificity, %	42.86	71.43	61.36	71.43	77.14	60.00	58.70	56.52
Accuracy, %	87.69	92.31	58.46	73.85	60.00	69.23	58.46	64.62
LR+	1.63	3.32	1.36	2.63	1.75	1.93	1.40	1.94
LR−	0.16	0.07	0.78	0.35	0.78	0.38	0.72	0.28
PPV, %	93.10	96.49	39.29	84.62	60.00	69.23	36.67	44.44
NPV, %	42.86	62.50	72.97	57.69	60.00	69.23	77.14	89.66
AUROC	0.59	0.87	0.48	0.77	0.48	0.71	0.55	0.68
ROC comparison by DeLong test
Area Difference	0.276		0.292		0.224		0.120
SE	0.196		0.082		0.072		0.072
Z Value	1.97		12.67		9.58		2.78
P Value	0.160		0.000		0.002		0.095

LR+ = positive likelihood ratio; LR − + negative likelihood ratio; PPV = positive predictive value; NPV = negative predictive value; AUROC = area under the receiver operating characteristic curve; SE = standard error.