Table 4. Studies reporting use of Pazopanib in uncommon/unclassified STS subtypes.
| Author | No. of patients (n) |
HPE subtype | ORR | PFS (months) | mOS (months) |
|---|---|---|---|---|---|
| Frezza et al [10] | 18 | Epithelioid sarcoma | 0% | 3 | NR |
| Touati et al [8] | 11 | Epithelioid sarcoma | 11.1% | 3.8 | 10.8 |
| Stacchiotti et al [37] | 30 | ASPS | 24.2% | 13.6 | NR |
| Kim et al [16] | 6 | ASPS | 16.7% | 5.5 | NR |
| Stacchiotti et al [38] | 26 | Extraskeletal myxoid chondrosarcoma | 18% | 2-year PFS – 40% |
NR |
| Kollár et al [18] | 52 | Angiosarcoma, haemangioendothelioma Intimal sarcoma | 20% 20% 100% |
3 NR NR |
9.9 NR NR |
| Martin-Broto et al [17] | 31 | Solitary fibrous tumour | 58% | 9.8 | 49.8 |
| Our study | 33 | Haemangiopericytoma, pleomorphic RMS (adult type), MFS, spindle cell sarcoma, MPNST, ASPS, haemangioendothelioma, epethelioid sarcoma, clear cell sarcoma, UPS. Retroperitoneal sarcoma, angiosarcoma | 27.2% | 10.3 | 17.8 |
NR, Not reported; HPE, Histopathological examination; ORR, Objective response rate; PFS, Progression free survival; OS, Overall survival; ASPS, Alveolar soft part sarcoma; MPNST, Malignant peripheral nerve sheath tumour; UPS, Undifferentiated pleomorphic sarcoma; RMS, Rhabdomyosarcoma