Table 3. HRs and CIs in univariate and multivariate analysis of PFS and OS.

Characteristics	2-year PFS univariate analysis HR	95% CI	p value	2-year PFS multivariate analysis HR (95% CI) p value	2-year OS univariate analysis HR	95% CI	p value	2-year OS multivariate analysis HR (95% CI) p value
Age	1.29	0.55–3.03	0.55	NA	0.77	0.31–1.89	0.57	NA
Sex	0.89	0.37–2.15	0.81	NA	1.39	0.57–3.44	0.47	NA
Location	0.67	0.29–1.56	0.36	NA	0.56	0.23–1.41	0.22	NA
Clinical N status	1.64	0.64–4.21	0.30	NA	2.17	0.82–5.80	0.12	NA
Radiological tumour length	1.16	0.50–2.69	0.73	NA	1.72	0.69–4.28	0.24	NA
PTV length	0.85	0.36–2.02	0.71	NA	1.04	0.42–2.55	0.94	NA
PTV volume	0.97	0.41–2.30	0.94	NA	1.67	0.67–4.15	0.27	NA
CROSS eligibility	2.29	0.98–5.39	0.05	2.36 (0.90–6.21) p = 0.08	1.91	0.79–4.62	0.15	2.05 (0.79–5.30) p = 0.14
TRG class	2.05	0.87–4.84	0.10	0.95 (0.18–4.90) p = 0.95	1.40	0.58–3.40	0.45	1.04 (0.22–4.95) p = 0.97
ypN	1.10	0.98–1.24	0.11	0.67 (0.21–2.13) p = 0.50	1.13	1.01–1.25	0.03	0.38 (0.11–1.35) p = 0.13
pCR	2.41	0.94–6.18	0.06	2.09 (0.30–14.34) p = 0.45	1.83	0.70–4.78	0.22	1.20 (0.17–8.34) p = 0.85

PFS, Progression free survival; OS, Overall survival; CI, Confidence Interval; HR, Hazard ratio; PTV, Planning target volume; pCR, Pathological complete response; TRG, Tumour regression grade; ypN, Pathological nodal status; NA, Not applicable