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. 2021 Sep 9;2(6):586–599. doi: 10.1158/2643-3230.BCD-21-0049

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©2021 The Authors; Published by the American Association for Cancer Research

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs International 4.0 License.

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Figure 3. — Genomic and transcriptional features of AMTL. Sixty-three cases spanning AML, AUL, MPAL, and ETP immunophenotypes shared a common transcriptional identity (see Fig. 1B). A, Mutational spectrum of AMTL cases. Del, deletion; Ins, insertion; LOH, loss of heterozygosity. B, Outcomes of patients with AMTL according to FLT3-ITD and PRC2 transcriptional identity. Dx, diagnosis; pOS, probability overall survival. C, Outcomes of FLT3-ITD/WT1 double-mutant cases based on AMTL and MK-V transcriptional identity (see Fig. 1). D, Expression of HOX locus genes in normal hematopoietic progenitor subsets and FLT3-ITD/WT1 cases from AMTL and MK-V transcriptional clusters. CMP, common myeloid progenitor; HSCP, HSC progenitor; LP, lymphoid-restricted progenitor. E, Enrichment of gene-expression signatures from HSC, CMP, and LP in FLT3-ITD/WT1 cases from AMTL and MK-V transcriptional clusters. n.s., not significant. F, pLSC6 score of FLT3-ITD/WT1 cases from AMTL and MK-V transcriptional clusters.