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. 2021 Sep 9;2(6):586–599. doi: 10.1158/2643-3230.BCD-21-0049

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©2021 The Authors; Published by the American Association for Cancer Research

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Figure 4. — Leukemia stemness is associated with overall survival. A, pLSC6 score was determined in normal hematopoietic progenitor subsets as previously described (17, 19). DC, dendritic cell; E, erythrocyte; G, granulocyte; GMP, granulocyte/macrophage progenitor; MEG, megakaryocyte; MEP, megakaryocyte/erythrocyte progenitor; NK, natural killer cell. B, pLSC6 scores from normal hematopoietic progenitors were used to define thresholds of low (lineage-committed cells), intermediate (multipotent progenitors), and high (pluripotent progenitors) values in our cohort. C, Imposing pLSC6 thresholds on our cohort found a subset of patients with intermediate and high scores that were significantly associated with overall survival (P = 9.3 × 10⁻⁷). Dx, diagnosis; pOS, probability overall survival. D, t-SNE visualization of the cohort with pLSC6 levels indicated. Thresholds of low, medium, and high as determined in A. B/M, B-lymphoid and myeloid coexpression; Ph-like, Philadelphia chromosome–like acute lymphoblastic leukemia; PTD, partial tandem duplication; Txn, transcription.