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. 2021 Nov 3;2021:4393266. doi: 10.1155/2021/4393266

Table 2.

Anticancer effects of quercetin against PC.

Dose In vitro/in vivo Cell line Effective mechanism Ref.
100 μM and 75 mg kg−1 In vivo and in vitro PANC-1 and Patu8988 EMT suppression by reducing TGF-β1 level, inhibition of growth, invasion, and migration of cells, apoptosis of cancer cells by antagonizing TGF-β/Smad and SHH signaling pathways [87]
20 μM In vitro Mia-PaCa-2 and PANC-1 Reduced IL-6 and IL-8 expressions and enhanced cytotoxicity against Mia-PaCa-2 and PANC-1 cell lines [89]
100 μM In vitro PANC-1 Reduced immunoreactivities such as ACTA-2, IL-1β, and N-cadherin, increased TNF-α and vimentin, prevention of EMT [139]
20 μM and 40 mg kg−1 In vivo and in vitro PDAC Improved effects of BET inhibitors at suppressing tumor development and reduced hnRNPA1 in vivo [93]
50-200 μM In vitro MIA Paca-2, BxPC-3, AsPC-1, HPAC and PANC-1 Quercetin showed a RAGE silencing like effect that attenuate RAGE expression to accelerate apoptosis, autophagy, and chemosensitivity of MIA Paca-2 GEMR cells [90]
20-80 μM In vitro PANC-1 and PATU-8988 Quercetin reversed IL-6-induced EMT by the stimulation of the STAT3 signaling pathway and prevented the migration [91]
50 μM In vivo AsPC-1 and PANC-1 Upregulation of miR-200b-3p that promoted the Notch signaling pathway of daughter cells to turn into symmetric [92]
50 μM In vitro AsPC-1, CRL-4023, and PANC-1 Notch inhibition by quercetin-induced let-7c and marker progression, upregulation of Numbl, and tumor development reduction [94]
100 nM In vitro CFPAC-1 and SNU-213 Suppressed TGF-β- and VEGF-A-induced migratory activity induced at low dosages in CFPAC-1, but not in bFGF-activated SNU-213 cells [140]