Figure 3.
Anti-inflammatory and anti-catabolic effects of MCC950. Mouse chondrocytes were pretreated with MCC950 for 2 h, then stimulated with 5 ng/ml IL-1β for 24 h. (a) Western blotting results of inflammatory mediators and matrix-degrading enzymes. (b) Quantification analysis of western blotting results. Data are shown as the mean ± SD. Significant differences between groups are indicated as #P < 0.05 vs. control group; ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 vs. IL-1β group.