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. 2021 Nov 3;2021:4139048. doi: 10.1155/2021/4139048

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Copyright © 2021 Bowei Ni et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Antioxidative effect of MCC950. Mouse chondrocytes were pretreated with MCC950 for 2 h, then stimulated with 5 ng/ml IL-1β for 24 h. (a) ROS production observed under a fluorescence microscope. Scale bar: 200 μm. (b) Flow cytometry results of ROS production. (c) Quantification analysis of the mean fluorescence intensity (MFI) of ROS in chondrocytes. ^#P < 0.05 vs. control group; ^∗P < 0.05 vs. IL-1β group. (d, e) Western blotting results and quantification analysis of Nrf2 nuclear/plasma protein expression. ^∗P < 0.05 vs. control group. (f, g) Western blotting results and quantification analysis of Nrf2/HO-1/NQO1 pathway proteins. ^∗P < 0.05 and ^∗∗P < 0.01 vs. control group.