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. 2021 Sep 1;4(4):321–331. doi: 10.31662/jmaj.2021-0077

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Figure 2. — Summary of Noradrenergic (ADRN)-type and Mesenchymal (MES)-type neuroblastoma. (Cited and modified from van Groningen T, Koster J, Valentijn LJ, et al. Neuroblastoma is composed of two super-enhancer-associated differentiation states. Nat Genet. 2017;49(8):1261-6 ⁽¹⁹⁾. Copyright of the figure belongs to the authors.)

Neuroblastoma was classified into Noradrenergic (ADRN)-type and Mesenchymal (MES)-type based on the superenhancer landscape of neuroblastoma. Commonly expressed genes during the course of neural crest differentiation and genetic abnormalities for each type are shown.