Table 2. Survival analysis of baseline variables according to disease progression in training cohort.

Variables	Univariate cox analysis			Multivariate cox analysis
	HR (95% CI)	P		HR (95% CI)	P
HR, hazard ratio; 95% CI, 95% confidence interval; NCRT, neoadjuvant chemoradiotherapy; CEA, carcinoma embryonic antigen; DTA, distance from inferior part of tumor to anal verge; CDTI, clock position of the deepest position of tumor invasion located at intestine wall; MRI, magnetic resonance imaging; EMVI, extramural venous invasion; DMRF, distance between the deepest tumor invasion and mesorectal fascia.
Age (year)		0.723
<56	1
≥56	0.94 (0.70−1.29)
Sex		0.292
Male	1
Female	0.83 (0.59−1.17)
Pre-NCRT cN stage		0.497
cN0	1
cN1−2	1.08 (0.88−1.32)
Pre-NCRT CEA (ng/mL)		0.247
<5	1
≥5	1.58 (0.72−3.48)
DTA (cm)		0.107
Lower (0−5)	1
Middle (6−10)	0.75 (0.54−1.03)	0.077
Upper (>10)	1.34 (0.65−2.77)	0.429
CDTI		<0.001			<0.001
Lateral (left/right)	1			1
Posterior/anterior	1.94 (1.38−2.74)			1.88 (1.33−2.65)
MRI EMVI		0.015			0.007
Negative	1			1
Positive	1.50 (1.09−2.08)			1.57 (1.13−2.18)
cT3 substage		0.055
a/b	1
c/d	1.51 (0.88−2.59)
DMRF category (mm)		<0.001			0.001
<7	1			1
≥7	0.26 (0.12−0.54)			0.26 (0.13−0.56)