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. 2021 Nov 10;28(11):879–888. doi: 10.1038/s41594-021-00674-7

Fig. 2. Transmembrane helix movement upon activation, and universal TM3 and TM6 helix ‘macroswitches’.

Fig. 2

a, Movements (Å) over 1.0 Å at the extracellular end, membrane mid (determined using ref. 43) and intracellular end of the transmembrane helices TM1–7 upon comparison of all available receptor inactive- and active-state structure pairs (Supplementary Table 1). Red intensity denotes the number of classes with a consensus. b, Movement and conserved hinges of TM6 and the adjacent TM5 and TM7. c, TM3 cytosolic tilt and overall rotation. b,c, GPCR class-representative inactive/active receptor structure pairs: A: β2 (refs. 44,45), B1: GLP-1 (refs. 18,22), C: GABAB246 and F: Smoothened47,48 receptors. Proline and glycine residues that increase helix plasticity are shown, along with their percentage conservation in the GPCR class.