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. 2021 Nov 10;28(11):879–888. doi: 10.1038/s41594-021-00674-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Heatmap of state determinants shared by at least two GPCR classes along with their consensus amino acid and residues in representative receptors. Each row contains corresponding positions denoted with the generic residue numbers in each class¹. Key class A state determinants are shown in bold.